Publications
2026
- Melanoma cells release dysfunctional mitochondria to the tumor microenvironment and circulation in association with tumor progression|Nicolás Georges-Calderón, Camila Fuentes, Yessia Hidalgo, Felipe Grunenwald, José Corrales-Bermúdez, Aliosha I. Figueroa-Valdés, Mirliana Ramírez-Pereira, Gloria Arriagada, Fernando J. Bustos, Constanza Ahumada-Marchant, Mercedes López, Francisca Alcayaga-Miranda. Cancer Letters. Volume 647, 1 June 2026, 218457. https://doi.org/10.1016/j.canlet.2026.218457
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Gene-Environment Interactions in Autism Spectrum Disorders: The Role of Bisphenol A in Modulating Genetic Susceptibility| Eduardo Quiñones-Medina, Felipe Galleguillos, Valentina Parra, Gloria Arriagada, Fernando J. Bustos, Autism Research, 19 January 2026, https://doi.org/10.1002/aur.70186
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Sex-specific alterations in CRF and dopaminergic markers in the lateral septum and mesolimbic system following chronic high-fat diet exposure in rats|Rossy Olivares-Barraza, José L Marcos , Jorge Escobar-Luna, María José Covarrubias, Georgina M Renard, Patricio Iturriaga-Vásquez, Katia Gysling,, Javier A Bravo, Marco Fuenzalida, Ramón Sotomayor-Zárate, Frontiers in Pharmacology, Sec. Experimental Pharmacology and Drug Discovery,Volume 17 – 2026, https://doi.org/10.3389/fphar.2026.1781720
- Adolescent ketamine exposure impairs spike timing-dependent plasticity and GABAergic transmission in pyramidal neurons of the mouse prefrontal cortex |Felipe Guiffa-Gómez, Sashá van Buuren, Freddy Aguilar, Juan Ahumada, Angélica Escobar, Ramon Sotomayor-Zárate, Koyam Morales-Weil, Marco Fuenzalida, The Journal of Physiology, 29 April 2026, https://doi.org/10.1113/JP290120
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Serotonin-endocannabinoid crosstalk selectively regulates inhibitory GABAergic inputs in the medial prefrontal cortex |Rodrigo C. Meza, Koyam Morales-Weil, Carlos Ancatén-González, Angélica P. Escobar, Alejandro Alcaino, Nicole Sanguinetti, Eric Delpire, Pablo R. Moya, Chiayu Q. Chiu, Marco Fuenzalida & Andrés E. Chávez, Neuropsychopharmacology, 51, pages 1474–1484, 2026, https://doi.org/10.1038/s41386-026-02364-8
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Transcriptomic signatures and neural cell composition in schizophrenia iPSC-derived neuron cultures |Bárbara S. Casas, Jorge M. Zúñiga-Hernández, Sebastián Arizábalos, Michel Maluenda, Claudio Letelier-Naritelli, Verónica Palma, Martín Montecino, Cells & Development, Volume 187, September 2026, 204097. https://doi.org/10.1016/j.cdev.2026.204097
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A recent and rapid genome expansion driven by the amplification of transposable elements in the Neotropical annual killifish Garcialebias charrua | Felipe Gajardo-Escobar, Camilo Valdivieso, Alex Di Genova, Luisa Pereiro, Maria Jose Arezo, Gino Nardocci, Natalia Rojas, Verónica Gutiérrez, Nicolás G. Papa, Nibia Berois, Alex Orellana, Rodrigo A. Gutiérrez, Mauricio González, Marco A. Mendez, Martín Montecino, Christian Hodar, Alvaro Glavic, Alejandro Maass, Graciela García & Miguel L. Allende, Biological Research , Volume 59, article number 1, 2026, https://doi.org/10.1186/s40659-025-00649-8
- Ethanol selectively disrupts neuronal microexon regulation and chromatin marks in PC12 cells | Montserrat Olivares-Costa, Pascal Jorratt, Camila Morales, Sebastián F Estay, Adrian R Krainer, María Estela Andrés, Paola A Haeger, Frontiers in Cellular Neuroscience,Sec. Cellular Neuropathology, 2026, https://doi.org/10.3389/fncel.2026.1854045
- Antioxidant and Cytoprotective Effects of Chilean Macroalgae Against Oxidative Stress-Induced Damage in Gastric Epithelial Cells |Samantha Acevedo-Correa,Paola A. Haeger, Francisco Álvarez, Michael Araya ,Fadia Tala, and Erwin de la Fuente-Ortega, Nutrients, 2026, https://doi.org/10.3390/nu18121878
- Red630 light transcranial LED therapy enhances mitochondrial function and synaptic integrity in the hippocampus, attenuating memory loss in aged SAMP8 mice |Claudia Jara, Leslye Venegas-Zamora, Alejandra Catenaccio, Ítalo Fuentes, Luis González, Matías Lira, Daniela Valenzuela-Bezanilla, Micaela Ricca, Sebastián Valenzuela, Lorena Varela-Nallar, Álvaro Ardiles, Pablo Muñoz, Débora Buendía & Cheril Tapia-Rojas, Cell Communication and Signaling, 2026, https://doi.org/10.1186/s12964-026-03078-6
- Viral-mediated fluorescent labelling of activated hippocampal memory engrams to study epigenetic dynamics associated with gene expression |Víctor Pola-Véliz, Sebastián B. Arredondo, Yennyfer Arancibia, Juan Ahumada, Sebastián Estay, Nicole Vidal, Paola A. Haeger, Marco Fuenzalida, Lorena Varela-Nallar, Fernando J. Bustos, Martin Montecino, Brigitte van Zundert, Methods,Volume 247, March 2026, Pages 85-94, https://doi.org/10.1016/j.ymeth.2026.01.004
- Reevaluating the role of skeletal muscle in amyotrophic lateral sclerosis pathogenesis: Insights from muscle-derived factors |Pablo Martinez, Brigitte van Zundert, Fernando J. Bustos Neural Regeneration Research, 21(7):p 2944-2945, 2026, , https://doi.org/10.4103/NRR.NRR-D-25-00567
2025
- The Ca2+ Bridge: From Neurons to Circuits in Rett Syndrome | Molina Calistro, L.; Arancibia, Y.; Alarcón, J.; Torres, R.F. The Ca2+Bridge: From Neurons to Circuits in Rett Syndrome.Int. J. Mol. Sci.2025,26, 10490. https://doi.org/10.3390/ijms262110490
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Neuroepigenetics Mechanisms in Health and Disease | Brigitte van Zundert, Martin Montecino (editores), https://doi.org/10.1007/978-3-031-75980-2
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Restoring endogenous Dlg4/PSD95 expression by an artificial transcription factor ameliorates cognitive and motor learning deficits in the R6/2 mouse model of Huntington’s disease | Fernández G, Leiva K, Bustos FJ, van Zundert B. Restoring endogenous Dlg4/PSD95 expression by an artificial transcription factor ameliorates cognitive and motor learning deficits in the R6/2 mouse model of Huntington’s disease. Clin Epigenetics. 2025 Jun 12;17(1):100. doi: 10.1186/s13148-025-01903-2 PMID: 40506760; PMCID: PMC12164150.
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Urban air pollution reduces H3K9me2/me3 in hippocampal and olfactory neurons, correlating with memory and social deficits | Nur Jury-Garfe, Mario Sánchez-Rubio, Gino Nardocci, Constanza Mercado, Nicolas Peña-Baeza, Pablo Ruiz-Rudolph, Martín Montecino, Lorena Varela-Nallar, Brigitte van Zundert, Urban air pollution reduces H3K9me2/me3 in hippocampal and olfactory neurons, correlating with memory and social deficits, Science of The Total Environment, Volume 997, 2025, 180145, ISSN 0048-9697,https://doi.org/10.1016/j.scitotenv.2025.180145
- Boldine as a neuroprotective agent against motor neuron degeneration in models of amyotrophic lateral sclerosis | Toro CA, Zhao W, Garcia Silva P, Retamal-Santibáñez D, Rojas F, Pan J, Johnson N, Duarte Y, Cardozo CP, Sáez JC, van Zundert B. Boldine as a neuroprotective agent against motor neuron degeneration in models of amyotrophic lateral sclerosis. Front Cell Neurosci. 2025 Sep 16;19:1640590. doi: 10.3389/fncel.2025.1640590. PMID: 41036176; PMCID: PMC12481613.
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Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media | Masegosa VM, Fritz E, Corvalan D, Rojas F, Garcés P, Navarro X, Bloms-Funke P, van Zundert B, Herrando-Grabulosa M. Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media. ACS Chem Neurosci. 2025 Aug 6;16(15):2887-2900. doi: 10.1021/acschemneuro.5c00197. Epub 2025 Jul 17. PMID: 40671688; PMCID: PMC12333588.
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Seasonal transcriptome profile across three different tissues of the Andean Killifish Orestias ascotanensis | Maldonado-Agurto, R., Acevedo, E., Maracaja-Coutinho, V. et al. Seasonal transcriptome profile across three different tissues of the Andean Killifish Orestias ascotanensis. Sci Data 12, 976 (2025). https://doi.org/10.1038/s41597-025-05345-6
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SKI regulates rRNA transcription and pericentromeric heterochromatin to ensure centromere integrity and genome stability | Pola-Véliz V, Carrero D, Sagredo EA, Inostroza V, Cappelli C, Rivas S, Bitrán M, Zambrano E, Gonzalez E, Morales F, Manterola M, Montecino M, Armisén R, Marcelain K. SKI regulates rRNA transcription and pericentromeric heterochromatin to ensure centromere integrity and genome stability. Neoplasia. 2025 Sep;67:101204. doi: 10.1016/j.neo.2025.101204 Epub 2025 Jul 2. PMID: 40609276; PMCID: PMC12270051.
2024
- Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death | Martínez, P., Silva, M., Abarzúa, S. et al. Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death. Mol Med 30, 185 (2024). https://doi.org/10.1186/s10020-024-00942-4
- Impact of KDM6B mosaic brain knockout on synaptic function and behavior | Brauer B, Ancatén-González C, Ahumada-Marchant C, Meza RC, Merino-Veliz N, Nardocci G, Varela-Nallar L, Arriagada G, Chávez AE, Bustos FJ. Impact of KDM6B mosaic brain knockout on synaptic function and behavior. Sci Rep. 2024 Sep 2;14(1):20416. doi: 10.1038/s41598-024-70728-5. PMID: 39223259; PMCID: PMC11369245.
- New therapeutics for the prevention or amelioration of fetal alcohol spectrum disorders: a narrative review of the preclinical literature | Olivares-Costa M, Fabio MC, De la Fuente-Ortega E, Haeger PA, Pautassi R. New therapeutics for the prevention or amelioration of fetal alcohol spectrum disorders: a narrative review of the preclinical literature. Am J Drug Alcohol Abuse. 2024 Jul 18:1-22. doi: 10.1080/00952990.2024.2361442. Epub ahead of print. PMID: 39023419.
- Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS/FTD | Garcés P, Amaro A, Montecino M, van Zundert B. Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS/FTD. Biochem Soc Trans. 2024 Feb 28;52(1):123-135. doi: 10.1042/BST20230257. PMID: 38323662.
- Maternal immune activation alters temporal precision of spike generation of CA1 pyramidal neurons by unbalancing GABAergic inhibition intheOffspring | Griego E, Cerna C, Sollozo-Dupont I, Fuenzalida M, Galván EJ. Maternal immune activation alters temporal precision of spike generation of CA1 pyramidal neurons by unbalancing GABAergic inhibition intheOffspring. Brain Behav Immun. 2024 Sep 16;123:211-228. doi: 10.1016/j.bbi.2024.09.012. Epub ahead of print. PMID: 39293693.
- Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior | Ahumada-Marchant C, Ancatén-Gonzalez C, Haensgen H, Arancibia F, Brauer B, Droste R, Horvitz HR, Constantine-Paton M, Arriagada G, Chávez AE, Bustos FJ. Deletion of VPS50 protein in mice brain impairs synaptic function and behavior. bioRxiv [Preprint]. 2023 Jul 5:2023.07.04.547745. doi: 10.1101/2023.07.04.547745. Update in: BMC Biol. 2024 Jun 26;22(1):142.